СÖíÊÓƵapp

Form: 4

Statement of changes in beneficial ownership of securities

September 5, 2008

FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Logal Adam
Ìý 2. Issuer Name and Ticker or Trading Symbol
Opko Health, Inc. [OPK]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director _____ 10% Owner
__X__ Officer (give title below) _____ Other (specify below)
Exec.Dir .of Fin., CAO,Treas.
(Last)
(First)
(Middle)
СÖíÊÓƵapp HEALTH, INC.,Ìý4400 BISCAYNE BOULEVARD, SUITE 1180
3. Date of Earliest Transaction (Month/Day/Year)
09/03/2008
(Street)

MIAMI,ÌýFLÌý33137
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 09/03/2008 Ìý M Ìý 16,600 A $ 0.56 16,600 D Ìý
Common Stock 09/03/2008 Ìý S Ìý 11,600 D $ 2.02 5,000 D Ìý
Common Stock 09/03/2008 Ìý S Ìý 5,000 D $ 1.93 0 D Ìý
Common Stock 09/04/2008 Ìý M Ìý 6,058 A $ 0.56 6,058 D Ìý
Common Stock 09/04/2008 Ìý S Ìý 5,000 D $ 2 1,058 D Ìý
Common Stock 09/04/2008 Ìý S Ìý 1,058 D $ 2.05 0 D Ìý

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number. SEC 1474 (9-02)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (Right to Buy) $ 0.56 09/03/2008 Ìý M Ìý Ìý 16,600 Ìý (1) 03/15/2017 Common Stock 16,600 $ 0 372,607 D Ìý
Stock Option (Right to Buy) $ 0.56 09/04/2008 Ìý M Ìý Ìý 6,058 Ìý (1) 03/15/2017 Common Stock 6,058 $ 0 366,549 D Ìý

Reporting Owners

Reporting Owner Name / Address Relationships
ÌýDirector Ìý10% Owner ÌýOfficer ÌýOther
Logal Adam
СÖíÊÓƵapp HEALTH, INC.
4400 BISCAYNE BOULEVARD, SUITE 1180
MIAMI,ÌýFLÌý33137
Ìý Ìý Ìý Exec.Dir .of Fin., CAO,Treas. Ìý

Signatures

Ìý/s/ Ìý 09/05/2008
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Of the original grant of 389,207 shares granted on March 15, 2007, 8,109 shares are exercisable monthly until fully vested on March 15, 2011.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.