小猪视频app

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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

FORM 10-Q

(Mark One)

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镁	听	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

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o	听	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Commission file number 001-33528

小猪视频app Health, Inc.

(Exact Name of Registrant as Specified in Its Charter)

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Delaware	听	75-2402409
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(State or Other Jurisdiction of Incorporation or Organization)	听	(I.R.S. Employer Identification No.)

4400 Biscayne Blvd.
Miami, FL 33137
(Address of Principal Executive Offices) (Zip Code)

(305)听575-4100

Indicate by check mark whether the registrant: (1)听has filed all reports required to be filed by Section听13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12听months (or for such shorter period that the registrant was required to file such reports), and (2)听has been subject to such filing requirements for the past 90听days. 镁 YES o NO

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule听405 of Regulation听S-T during the preceding 12听months (or for such shorter period that the registrant was required to submit and post such files). YES o NO o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of 聯large accelerated filer,聰 聯accelerated filer聰 and 聯smaller reporting company聰 (in Rule听12b-2 of the Exchange Act) (Check one):

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Large accelerated filer o	听	Accelerated filer 镁	听	Non-accelerated filer o (Do not check if a smaller reporting company)	听	Smaller reporting company o

Indicate by check mark whether the registrant is a shell company (as defined in Rule听12b-2 of the Exchange Act): YES o NO 镁

As of May听1, 2011, the registrant had 285,060,055 shares of common stock outstanding.

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PART I. FINANCIAL INFORMATION	听	听	听	听
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Item听1. Financial Statements	听	听	听	听
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Condensed Consolidated Balance Sheets as of March听31, 2011 and December听31, 2010 (unaudited)	听	听	6	听
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Condensed Consolidated Statements of Operations for the three months ended March听31, 2011 and March听31, 2010 (unaudited)	听	听	7	听
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Condensed Consolidated Statements of Cash Flows for the three months ended March听31, 2011 and March听31, 2010 (unaudited)	听	听	8	听
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Notes to Financial Statements	听	听	9	听
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Item听2. Management聮s Discussion and Analysis of Financial Condition and Results of Operations	听	听	22	听
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Item听3. Quantitative and Qualitative Disclosures About Market Risk	听	听	26	听
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Item听4. Controls and Procedures	听	听	27	听
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PART II. OTHER INFORMATION	听	听	听	听
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Item听1. Legal Proceedings	听	听	27	听
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Item听1A. Risk Factors	听	听	27	听
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Item听2. Unregistered Sales of Equity Securities and Use of Proceeds	听	听	28	听
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Item听3. Defaults Upon Senior Securities	听	听	28	听
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Item听4. (Removed and Reserved)	听	听	28	听
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Item听5. Other Information	听	听	28	听
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Item听6. Exhibits	听	听	28	听
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Signatures	听	听	30	听
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Exhibit听Index	听	听	31	听
听EX-2.4
听EX-10.1
听EX-10.2
听EX-31.1
听EX-31.2
听EX-32.1
听EX-32.2

CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTS

听听听听听This Quarterly Report on Form 10-Q contains 聯forward-looking statements,聰 as that term is defined under the Private Securities Litigation Reform Act of 1995, or PSLRA, Section听27A of the Securities Act of 1933, as amended, and Section听21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements include statements about our expectations, beliefs or intentions regarding our product development efforts, business, financial condition, results of operations, strategies or prospects. You can identify forward-looking statements by the fact that these statements do not relate strictly to historical or current matters. Rather, forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward-looking statements. These factors include those described below and in 聯Item听1A-Risk Factors聰 of our Annual Report on Form 10-K for the year ended December听31, 2010, and described from time to time in our reports filed with the Securities and Exchange Commission. Except as required by law, we do not undertake any obligation to update forward-looking statements. We intend that all forward-looking statements be subject to the safe-harbor provisions of the PSLRA. These forward-looking statements are only predictions and reflect our views as of the date they are made with respect to future events and financial performance.

听听听听听Risks and uncertainties, the occurrence of which could adversely affect our business, include the following:

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We have a history of operating losses and we do not expect to become profitable in the near future.

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Our technologies are in an early stage of development and are unproven.

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Our drug research and development activities may not result in commercially viable products.

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The results of previous clinical trials may not be predictive of future results, and our current and planned clinical trials may not satisfy the requirements of the FDA or other non-U.S. regulatory authorities.

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We will require substantial additional funding, which may not be available to us on acceptable terms, or at all.

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Our business is substantially dependant on our ability to develop, launch and generate revenue from our molecular diagnostic program.

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We expect to finance future cash needs primarily through public or private offerings, debt financings or strategic collaborations, which may dilute your stockholdings in the Company.

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If our competitors develop and market products that are more effective, safer or less expensive than our future product candidates, our commercial opportunities will be negatively impacted.

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The regulatory approval process is expensive, time consuming and uncertain and may prevent us or our collaboration partners from obtaining approvals for the commercialization of some or all of our product candidates.

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Failure to recruit and enroll patients for clinical trials may cause the development of our product candidates to be delayed.

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Even if we obtain regulatory approvals for our product candidates, the terms of approvals and ongoing regulation of our products may limit how we manufacture and market our product candidates, which could materially impair our ability to generate anticipated revenues.

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We may not meet regulatory quality standards applicable to our manufacturing and quality processes.

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Even if we receive regulatory approval to market our product candidates, the market may not be receptive to our products.

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If we fail to attract and retain key management and scientific personnel, we may be unable to successfully develop or commercialize our product candidates.

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In the event that we successfully evolve from a company primarily involved in development to a company also involved in commercialization, we may encounter difficulties in managing our growth and expanding our operations successfully.

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If we fail to acquire and develop other products or product candidates, at all or on commercially reasonable terms, we may be unable to diversify or grow our business.

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We have no experience manufacturing our pharmaceutical product candidates other than our Mexican facility and we therefore rely on third parties to manufacture and supply our pharmaceutical product candidates, and would need to meet various standards necessary to satisfy FDA regulations if and when we commence manufacturing.

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We currently have no pharmaceutical or diagnostic marketing, sales or distribution capabilities other than in Chile and Mexico for sales in those countries. If we are unable to develop our sales and marketing and distribution capability on our own or through collaborations with marketing partners, we will not be successful in commercializing our pharmaceutical product candidates.

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Independent clinical investigators and contract research organizations that we engage to conduct our clinical trials may not be diligent, careful or timely.

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The success of our business is dependent on the actions of our collaborative partners.

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Our license agreement with TESARO, Inc. is important to our business. If TESARO does not successfully develop and commercialize rolapitant, our business could be adversely affected.

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If we are unable to obtain and enforce patent protection for our products, our business could be materially harmed.

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We do not have an exclusive arrangement in place with Dr.听Tom Kodadek with respect to technology or intellectual property that may be material to our business.

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If we are unable to protect the confidentiality of our proprietary information and know-how, the value of our technology and products could be adversely affected.

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We rely heavily on licenses from third parties.

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We license patent rights to certain of our technology from third-party owners. If such owners do not properly maintain or enforce the patents underlying such licenses, our competitive position and business prospects will be harmed.

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Our commercial success depends significantly on our ability to operate without infringing the patents and other proprietary rights of third parties.

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Adverse results in material litigation matters or governmental inquiries could have a material adverse effect upon our business and financial condition.

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Medicare prescription drug coverage legislation and future legislative or regulatory reform of the health care system may affect our ability to sell our products profitably.

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Failure to obtain regulatory approval outside the United States will prevent us from marketing our product candidates abroad.

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We may not have the funding available to pursue acquisitions.

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Acquisitions may disrupt our business, distract our management and may not proceed as planned; and we may encounter difficulties in integrating acquired businesses.

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Non-U.S. governments often impose strict price controls, which may adversely affect our future profitability.

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Our business may become subject to legal, economic, political, regulatory and other risks associated with international operations.

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The market price of our common stock may fluctuate significantly.

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Directors, executive officers, principal stockholders and affiliated entities own a significant percentage of our capital stock, and they may make decisions that you do not consider to be in your best interests or in the best interests of our stockholders.

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Compliance with changing regulations concerning corporate governance and public disclosure may result in additional expenses.

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If we are unable to satisfy the requirements of Section听404 of the Sarbanes-Oxley Act of 2002, as they apply to us, or our internal controls over financial reporting are not effective, the reliability of our financial statements may be questioned and our common stock price may suffer.

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We may be unable to maintain our listing on the NYSE Amex, which could cause our stock price to fall and decrease the liquidity of our common stock.

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Future issuances of common stock and hedging activities may depress the trading price of our common stock.

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Provisions in our charter documents and Delaware law could discourage an acquisition of us by a third party, even if the acquisition would be favorable to you.

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We do not intend to pay cash dividends on our common stock in the foreseeable future.

PART I. FINANCIAL INFORMATION

听听听听听Unless the context otherwise requires, all references in this Quarterly Report on Form 10-Q to the 聯Company聰, 聯小猪视频app聰, 聯we聰, 聯our聰, 聯ours聰, and 聯us聰 refer to 小猪视频app Health, Inc., a Delaware corporation, including our wholly-owned subsidiaries.

Item听1. Financial Statements

小猪视频app Health, Inc. and Subsidiaries

CONDENSED CONSOLIDATED BALANCE SHEETS
(unaudited) (in thousands except share data)

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听	听	March 31, 2011		听	听	December 31, 2010		听
ASSETS	听	听	听	听	听	听	听	听
Current assets	听	听	听	听	听	听	听	听
Cash and cash equivalents	听	$	47,879	听	听	$	18,016	听
Marketable securities	听	听	59,983	听	听	听	聴	听
Accounts receivable, net	听	听	14,001	听	听	听	13,317	听
Inventory, net	听	听	18,137	听	听	听	19,957	听
Prepaid expenses and other current assets	听	听	2,785	听	听	听	2,782	听
听	听	听		听	听	听		听
Total current assets	听	听	142,785	听	听	听	54,072	听
Property and equipment, net	听	听	2,771	听	听	听	2,729	听
Intangible assets, net	听	听	19,355	听	听	听	9,964	听
Goodwill	听	听	6,672	听	听	听	5,856	听
Investments	听	听	4,691	听	听	听	5,114	听
Other assets	听	听	33	听	听	听	111	听
听	听	听		听	听	听		听
Total assets	听	$	176,307	听	听	$	77,846	听
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LIABILITIES, SERIES D PREFERRED STOCK, AND SHAREHOLDERS聮 EQUITY	听	听	听	听	听	听	听	听
Current liabilities	听	听	听	听	听	听	听	听
Accounts payable	听	$	4,574	听	听	$	7,170	听
Accrued expenses	听	听	5,557	听	听	听	5,739	听
Current portion of lines of credit	听	听	14,552	听	听	听	14,690	听
听	听	听		听	听	听		听
Total current liabilities	听	听	24,683	听	听	听	27,599	听
Long-term liabilities	听	听	1,883	听	听	听	1,067	听
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Total liabilities	听	听	26,566	听	听	听	28,666	听
听	听	听	听	听	听	听	听	听
Commitments and contingencies	听	听	听	听	听	听	听	听
听	听	听	听	听	听	听	听	听
Series听D preferred stock 聴 $0.01 par value, 2,000,000 shares authorized; 1,209,677 and 1,209,677 shares issued and outstanding (liquidation value of $33,613 and $33,013) at March听31, 2011 and December听31, 2010, respectively	听	听	26,128	听	听	听	26,128	听
听	听	听	听	听	听	听	听	听
Shareholders聮 equity	听	听	听	听	听	听	听	听
Series听A Preferred stock 聴 $0.01 par value, 4,000,000 shares authorized; 722,700 and 897,439 shares issued and outstanding (liquidation value of $2,076 and $2,468) at March听31, 2011 and December听31, 2010, respectively	听	听	7	听	听	听	9	听
Series听C Preferred Stock 聴 $0.01 par value, 500,000 shares authorized; No shares issued or outstanding	听	听	聴	听	听	听	聴	听
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Common Stock 聴 $0.01 par value, 500,000,000 shares authorized; 285,042,867 and 255,412,706 shares issued and outstanding at March听31, 2011 and December听31, 2010, respectively	听	听	2,850	听	听	听	2,554	听
Treasury stock - 45,154 shares at March听31, 2011 and December听31, 2010	听	听	(61	)	听	听	(61	)
Additional paid-in capital	听	听	482,521	听	听	听	376,008	听
Accumulated other comprehensive income	听	听	2,424	听	听	听	2,921	听
Accumulated deficit	听	听	(364,128	)	听	听	(358,379	)
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Total shareholders聮 equity	听	听	123,613	听	听	听	23,052	听
听	听	听		听	听	听		听
Total liabilities, Series听D Preferred Stock, and shareholders聮 equity	听	$	176,307	听	听	$	77,846	听
听	听	听		听	听	听		听

The accompanying Notes to Condensed Consolidated Financial Statements are an integral part of these statements.

小猪视频app Health, Inc. and Subsidiaries

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
(unaudited)
(in thousands, except share data)

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听	听	For the three months ended March 31,						听
听	听	2011		听	听	2010		听
Revenue	听	听	听	听	听	听	听	听
Product sales	听	$	8,635	听	听	$	7,922	听
Other revenue	听	听	13	听	听	听	聴	听
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Total revenue	听	听	8,648	听	听	听	7,922	听
Cost of goods sold, excluding amortization of intangible assets	听	听	5,623	听	听	听	5,528	听
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Gross margin, excluding amortization of intangible assets	听	听	3,025	听	听	听	2,394	听
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Operating expenses	听	听	听	听	听	听	听	听
Selling, general and administrative	听	听	5,586	听	听	听	4,243	听
Research and development	听	听	1,645	听	听	听	1,328	听
Other operating expenses, principally amortization of intangible assets	听	听	880	听	听	听	889	听
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Total operating expenses	听	听	8,111	听	听	听	6,460	听
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Operating loss	听	听	(5,086	)	听	听	(4,066	)
Other income (expense), net	听	听	38	听	听	听	(340	)
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Loss before income taxes and investment losses	听	听	(5,048	)	听	听	(4,406	)
Income tax provision	听	听	233	听	听	听	47	听
听	听	听		听	听	听		听
Loss before investment losses	听	听	(5,281	)	听	听	(4,453	)
Loss from investments in investees	听	听	(423	)	听	听	(231	)
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Net loss	听	听	(5,704	)	听	听	(4,684	)
Preferred stock dividend	听	听	(645	)	听	听	(662	)
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Net loss attributable to common shareholders	听	$	(6,349	)	听	$	(5,346	)
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Loss per share, basic and diluted	听	$	(0.02	)	听	$	(0.02	)
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听	听	听	听	听	听	听	听	听
Weighted average number of common shares outstanding, basic and diluted	听	听	261,042,274	听	听	听	254,452,451	听

The accompanying Notes to Condensed Consolidated Financial Statements are an integral part of these statements.

小猪视频app Health, Inc. and Subsidiaries

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
(unaudited)
(in thousands)

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听	听	For the three months ended March 31,						听
听	听	2011		听	听	2010		听
Cash flows from operating activities	听	听	听	听	听	听	听	听
Net loss	听	$	(5,704	)	听	$	(4,684	)
Adjustments to reconcile net loss to net cash used in operating activities:	听	听	听	听	听	听	听	听
Depreciation and amortization	听	听	997	听	听	听	971	听
Accretion of debt discount related to notes payable	听	听	2	听	听	听	60	听
Equity-based compensation 聴 employees and non-employees	听	听	1,754	听	听	听	1,205	听
Loss from investments in investees	听	听	423	听	听	听	231	听
Provision for (recovery of) bad debt	听	听	28	听	听	听	(10	)
Provision for (reversal of) inventory reserves	听	听	62	听	听	听	(63	)
Changes in:	听	听	听	听	听	听	听	听
Accounts receivable	听	听	(598	)	听	听	(1,668	)
Inventory	听	听	1,391	听	听	听	885	听
Prepaid expenses and other current assets	听	听	(379	)	听	听	(272	)
Other assets	听	听	80	听	听	听	103	听
Accounts payable	听	听	(2,487	)	听	听	513	听
Accrued expenses	听	听	(254	)	听	听	50	听
听	听	听		听	听	听		听
Net cash used in operating activities	听	听	(4,685	)	听	听	(2,679	)
听	听	听		听	听	听		听
Cash flows from investing activity	听	听	听	听	听	听	听	听
Acquisition of businesses, net of cash	听	听	(10,538	)	听	听	(1,447	)
Purchase of marketable securities	听	听	(59,983	)	听	听	(4,999	)
Capital expenditures	听	听	(108	)	听	听	(203	)
听	听	听		听	听	听		听
Net cash used in investing activity	听	听	(70,629	)	听	听	(6,649	)
听	听	听		听	听	听		听
Cash flows from financing activities:	听	听	听	听	听	听	听	听
Issuance of common stock, including related parties, net	听	听	104,828	听	听	听	聴	听
Borrowing under lines of credit	听	听	3,027	听	听	听	1,165	听
Repayments under lines of credit	听	听	(2,827	)	听	听	(821	)
Proceeds from the exercise of stock options and warrants	听	听	135	听	听	听	2	听
Repayments of notes payable and capital lease obligations	听	听	聴	听	听	听	(2	)
听	听	听		听	听	听		听
Net cash provided by financing activities	听	听	105,163	听	听	听	344	听
Effect of exchange rate changes on cash and cash equivalents	听	听	14	听	听	听	聴	听
听	听	听		听	听	听		听
Net increase (decrease)听in cash and cash equivalents	听	听	29,863	听	听	听	(8,984	)
Cash and cash equivalents at beginning of period	听	听	18,016	听	听	听	42,658	听
听	听	听		听	听	听		听
Cash and cash equivalents at end of period	听	$	47,879	听	听	$	33,674	听
听	听	听		听	听	听		听
听	听	听	听	听	听	听	听	听
SUPPLEMENTAL INFORMATION	听	听	听	听	听	听	听	听
Interest paid	听	$	65	听	听	$	46	听
Issuance of capital stock to acquire Exakta-小猪视频app	听	$	聴	听	听	$	1,999	听

The accompanying Notes to Condensed Consolidated Financial Statements are an integral part of these statements.

小猪视频app Health, Inc. and Subsidiaries

NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (unaudited)

NOTE 1 BUSINESS AND ORGANZATION

听听听听听We are a multi-national pharmaceutical and diagnostics company that seeks to establish industry-leading positions in large and rapidly growing medical markets by leveraging our discovery, development and commercialization expertise and our novel and proprietary technologies. Our current focus is on conditions with major unmet medical needs including neurological disorders, infectious diseases, oncology and ophthalmologic diseases. We are developing a range of solutions to diagnose, treat and prevent these conditions, including molecular diagnostics tests, proprietary pharmaceuticals and vaccines. We plan to commercialize these solutions on a global basis in large and high growth markets, including emerging markets. We have already established emerging markets pharmaceutical platforms in Chile and Mexico, which are delivering revenue and which we expect to deliver cash flow and facilitate future market entry for our products currently in development. We also actively explore opportunities to acquire complementary pharmaceuticals, compounds, technologies, and businesses. We are a Delaware corporation, headquartered in Miami, Florida.

NOTE 2 SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

听听听听听Basis of presentation. The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States and with the instructions to Form 10-Q and Article听10 of Regulation听S-X. Accordingly, they do not include all information and notes required by accounting principles generally accepted in the United States for complete financial statements. In the opinion of management, all adjustments (consisting of only normal recurring adjustments) considered necessary to present fairly the Company聮s results of operations, financial position and cash flows have been made. The results of operations and cash flows for the three months ended March听31, 2011, are not necessarily indicative of the results of operations and cash flows that may be reported for the remainder of 2011 or for future periods. The unaudited condensed consolidated financial statements should be read in conjunction with the Consolidated Financial Statements and the Notes to Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December听31, 2010.

听听听听听Principles of consolidation. The accompanying unaudited condensed consolidated financial statements include the accounts of 小猪视频app Health, Inc. and our wholly-owned subsidiaries. All significant intercompany accounts and transactions are eliminated in consolidation.

听听听听听Use of Estimates. The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

听听听听听Cash and Cash Equivalents. Cash and cash equivalents consist of short-term, interest-bearing instruments with original maturities of 90听days or less at the date of purchase. We also consider all highly liquid investments with original maturities at the date of purchase of 90听days or less as cash equivalents. These investments include money markets, bank deposits, and U.S. treasury securities.

听听听听听Marketable securities. Investments with original maturities of greater than 90听days and remaining maturities of less than one year are classified as marketable securities. Marketable securities include U.S. treasury securities. Unrealized gains and temporary losses on investments are included in accumulated other comprehensive income (loss)听as a separate component of stockholders聮 equity. Realized gains and losses, dividends, interest income, and declines in value judged to be other-than-temporary credit losses are included in other income (expense). Amortization of any premium or discount arising at purchase is included in interest income.

听听听听听Comprehensive loss. Our comprehensive loss for the three months ended March听31, 2011 was $6.2 million and includes our net loss and the cumulative translation adjustment, net, for the translation of our subsidiaries in Chile and Mexico. Comprehensive loss for the three months ended March听31, 2010 was $5.0听million and includes our net loss for the three months and the cumulative translation adjustment, net, for the translation of the results of our subsidiaries in Chile and Mexico.

听听听听听Revenue recognition. Generally, we recognize revenue from product sales when goods are shipped and title and risk of loss transfer to our customers. Certain of our instrumentation products are sold directly to end-users and require that we deliver, install and train the staff at the end-users聮 facility. As a result, we do not recognize revenue until the product is delivered, installed and training has occurred for instrumentation products sold to end-users.

听听听听听Other revenues include revenue related to upfront license payments, license fees and milestone payments received through our license, collaboration and commercialization agreements. We analyze our multiple-element arrangements to determine whether the elements can be separated and accounted for individually as separate units of accounting.

听听听听听Non-refundable license fees for the out-license of our technology are recognized depending on the provisions of each agreement. We recognize non-refundable upfront license payments as revenue upon receipt if the license has standalone value and the fair value of our undelivered obligations, if any, can be determined. If the license is considered to have standalone value but the fair value of any of the undelivered items cannot be determined, the license payments are recognized as revenue over the period of our performance for such undelivered items or services. License fees with ongoing involvement or performance obligations are recorded as deferred revenue once received and generally are recognized ratably over the period of such performance obligation only after both the license period has commenced and we have delivered the technology. Our assessment of our obligations and related performance periods requires significant management judgment. If an agreement contains research and development obligations, the relevant time period for the research and development phase is based on management estimates and could vary depending on the outcome of clinical trials and the regulatory approval process. Such changes could materially impact the revenue recognized, and as a result, management reviews the estimates related to the relevant time period of research and development on a quarterly basis.

听听听听听Revenue from milestone payments related to arrangements under which we have continuing performance obligations are recognized as revenue upon achievement of the milestone only if all of the following conditions are met: the milestone payments are non-refundable; there was substantive uncertainty at the date of entering into the arrangement that the milestone would be achieved; the milestone is commensurate with either the vendor聮s performance to achieve the milestone or the enhancement of the value of the delivered item by the vendor; the milestone relates solely to past performance; and the amount of the milestone is reasonable in relation to the effort expended or the risk associated with the achievement of the milestone. If any of these conditions are not met, the milestone payments are not considered to be substantive and are, therefore, deferred and recognized as revenue over the term of the arrangement as we complete our performance obligations.

听听听听听Total deferred revenue related to other revenues was $0.2听million and $0.2听million at March 31, 2011 and December听31, 2010, respectively.

听听听听听Derivative financial instruments. We record derivative financial instruments on our balance sheet at their fair value and the changes in the fair value are recognized in income when they occur, the only exception being derivatives that qualify as hedges. To qualify the derivative instrument as a hedge, we are required to meet strict hedge effectiveness and contemporaneous documentation requirements at the initiation of the hedge and assess the hedge effectiveness on an ongoing basis over the life of the hedge. At March听31, 2011 and December听31, 2010, our forward contracts for inventory purchases did not meet the documentation requirements to be designated as hedges. Accordingly, we recognize all changes in fair values in income. Refer to Note 7.

听听听听听Product warranties. Product warranty expense is recorded concurrently with the recording of revenue for product sales. The costs of warranties are accounted for as a component of cost of sales. We estimate warranty costs based on our estimated historical experience and adjust for any known product reliability issues.

听听听听听Allowance for doubtful accounts. We analyze accounts receivable and historical bad debt levels, customer credit worthiness and current economic trends when evaluating the adequacy of the allowance for doubtful accounts using the specific identification method. Our reported net loss is directly affected by our estimate of the collectability of accounts receivable. Estimated allowances for sales returns are based upon our history of product returns. The amount of allowance for doubtful accounts was $1.2听million at March听31, 2011 and December听31, 2010.

听听听听听Segment reporting. Our chief operating decision-maker (聯CODM聰) is comprised of our executive management with the oversight of our board of directors. Our CODM review our operating results and operating plans and make resource allocation decisions on a company-wide or aggregate basis. Accordingly, we have aggregated our three operating segments, instrumentation, pharmaceutical operating business and pharmaceutical research and

development activities into two reporting segments, instrumentation and pharmaceutical as we expect the businesses to have similar long-term economic characteristics.

听听听听听Equity-based compensation. We measure the cost of employee services received in exchange for an award of equity instruments based on the grant-date fair value of the award. That cost is recognized in the statement of operations over the period during which an employee is required to provide service in exchange for the award. We record excess tax benefits, realized from the exercise of stock options as a financing cash inflow rather than as a reduction of taxes paid in cash flow from operations. Equity-based compensation arrangements to non-employees are recorded at their fair value on the measurement date. The measurement of equity-based compensation is subject to periodic adjustment as the underlying equity instruments vest. During the three months ended March听31, 2011 and 2010, we recorded $1.8听million and $1.2听million, respectively, of equity-based compensation expense.

听听听听听Recent accounting pronouncements. In December听2010, the FASB issued an amendment to the disclosure of supplementary pro forma information for business combinations. The amendment specifies that if a public entity presents comparative financial statements, the entity should disclose revenue and earnings of the combined entity as though the business combination(s) that occurred during the current year had occurred as of the beginning of the comparable prior annual reporting period only. The amendment also expands the supplemental pro forma disclosures under current accounting guidance to include a description of the nature and amount of material, nonrecurring pro forma adjustments directly attributable to the business combination included in the reported pro forma revenue and earnings. The amendment is effective prospectively for business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December听15, 2010. The adoption of this amendment did not have a material impact on our financial statement disclosures.

听听听听听In December听2010, the FASB issued an amendment to the accounting for goodwill impairment tests. The amendment modifies Step 1 of the impairment test for reporting units with zero or negative carrying amounts. For those reporting units, an entity is required to perform Step 2 of the goodwill impairment test if it is more likely than not that a goodwill impairment exists. In determining whether it is more likely than not that a goodwill impairment exists, an entity should consider whether there are any adverse qualitative factors indicating that an impairment may exist. The qualitative factors are consistent with the existing guidance. The amendment is effective for fiscal years, and interim periods within those years, beginning after December听15, 2010. The adoption of this amendment did not have a material impact on our results of operations or financial condition.

听听听听听In December听2010, the FASB issued an amendment to the accounting for annual excise taxes paid to the federal government by pharmaceutical manufacturers under health care reform. The liability for the fee should be estimated and recorded in full upon the first qualifying branded prescription drug sale with a corresponding deferred cost that is amortized to expense using a straight-line method of allocation unless another method better allocates the fee over the calendar year that it is payable. The amendment is effective for calendar years beginning after December听31, 2010, when the fee initially becomes effective. As we currently do not manufacture pharmaceutical products in the United States, we do not expect the adoption of this amendment to have a material impact on our results of operations or financial condition.

听听听听听In March听2010, the FASB reached a consensus to issue an amendment to the accounting for revenue arrangements under which a vendor satisfies its performance obligations to a customer over a period of time, when the deliverable or unit of accounting is not within the scope of other authoritative literature, and when the arrangement consideration is contingent upon the achievement of a milestone. The amendment defines a milestone and clarifies whether an entity may recognize consideration earned from the achievement of a milestone in the period in which the milestone is achieved. This amendment is effective for fiscal years beginning on or after June听15, 2010, with early adoption permitted. We adopted this amendment prospectively for milestones achieved after January听1, 2011. This amendment did not have a material impact on our results of operation or financial condition.

听听听听听In October听2009, the FASB issued an amendment to the accounting for multiple-deliverable revenue arrangements. This amendment provides guidance on whether multiple deliverables exist, how the arrangements should be separated, and how the consideration paid should be allocated. As a result of this amendment, entities may be able to separate multiple-deliverable arrangements in more circumstances than under existing accounting guidance. This guidance amends the requirement to establish the fair value of undelivered products and services based on objective evidence and instead provides for separate revenue recognition based upon management聮s best estimate of the selling price for an undelivered item when there is no other means to determine the fair value of that undelivered item. The existing guidance previously required that the fair value of the undelivered item reflect the price of the item either sold in a separate transaction between unrelated third parties or the price charged for each

item when the item is sold separately by the vendor. If the fair value of all of the elements in the arrangement was not determinable, then revenue was deferred until all of the items were delivered or fair value was determined. We adopted this amendment prospectively for revenue arrangements entered into or materially modified after January听1, 2011. This amendment did not have a material impact on our results of operation or financial condition.

NOTE 3 LOSS PER SHARE

听听听听听Basic loss per share is computed by dividing our net loss by the weighted average number of shares outstanding during the period. Diluted earnings per share is computed by dividing our net loss by the weighted average number of shares outstanding and the impact of all dilutive potential common shares, primarily stock options. The dilutive impact of stock options and warrants are determined by applying the 聯treasury stock聰 method.

听听听听听A total of 28,506,408 and 19,071,146 potential common shares have been excluded from the calculation of net loss per share for the three months ended March听31, 2011 and 2010, respectively, because their inclusion would be anti-dilutive. As of March听31, 2011, the holders of our Series听A Preferred Stock and Series听D Preferred Stock could convert their Preferred Shares into approximately 830,511 and 13,553,759 shares of our Common Stock, respectively.

NOTE 4 COMPOSITION OF CERTAIN FINANCIAL STATEMENT CAPTIONS

听	听	听	听	听	听	听	听	听
听	听	March 31,		听	听	December 31,		听
(in thousands)	听	2011		听	听	2010		听
Accounts receivable, net:	听	听	听	听	听	听	听	听
Accounts receivable	听	$	15,184	听	听	$	14,482	听
Less allowance for doubtful accounts	听	听	(1,183	)	听	听	(1,165	)
听	听	听		听	听	听		听
听	听	$	14,001	听	听	$	13,317	听
听	听	听		听	听	听		听
Inventories, net:	听	听	听	听	听	听	听	听
Raw materials (components)	听	$	4,784	听	听	$	4,868	听
Work-in process	听	听	1,222	听	听	听	889	听
Finished products	听	听	12,634	听	听	听	14,632	听
Less inventory reserve	听	听	(503	)	听	听	(432	)
听	听	听		听	听	听		听
听	听	$	18,137	听	听	$	19,957	听
听	听	听		听	听	听		听
Intangible assets, net:	听	听	听	听	听	听	听	听
Customer relationships	听	$	7,506	听	听	$	7,719	听
Technology	听	听	14,597	听	听	听	4,597	听
Product registrations	听	听	4,232	听	听	听	4,227	听
Tradename	听	听	662	听	听	听	666	听
Covenants not to compete	听	听	387	听	听	听	349	听
Other	听	听	297	听	听	听	7	听
Less accumulated amortization	听	听	(8,326	)	听	听	(7,601	)
听	听	听		听	听	听		听
听	听	$	19,355	听	听	$	9,964	听
听	听	听		听	听	听		听

The change in value of the intangible assets include the foreign currency fluctuation between the Chilean and Mexican pesos against the US dollar at March听31, 2011 and December听31, 2010. The increase in technology and other reflects the acquisition of CURNA, Inc. Refer to Note 5.

NOTE 5 ACQUISITIONS, INVESTMENTS, AND LICENSES

CURNA acquisition

听听听听听In January听2011, we acquired all of the outstanding stock of CURNA, Inc., (聯CURNA聰) in exchange for $10.0听million in cash, plus $0.6听million in liabilities, of which, $0.5 million was paid at closing. In addition to the cash consideration, we have agreed to pay to the CURNA sellers a portion of any consideration we receive in connection with certain license, partnership or collaboration agreements we may enter into with third parties in the future relating to the CURNA technology, including, license fees, upfront payments, royalties and milestone payments. As a result, we recorded $0.6听million, as contingent consideration for the future consideration.

We will evaluate the contingent consideration on an ongoing basis and the changes in fair value will be recognized in earnings until the contingencies are resolved. CURNA was a privately held company based in Jupiter, Florida, engaged in the discovery of new drugs for the treatment of a wide variety of illnesses, including cancer, heart disease, metabolic disorders and a range of genetic anomalies.

听听听听听The following table reflects the estimated fair value of the net assets acquired at the date of acquisition:

听	听	听	听	听
(in thousands)	听	听	听	听
Current assets (including cash of $5)	听	$	38	听
Fixed assets	听	听	21	听
Intangible assets	听	听	听	听
Technology	听	听	10,000	听
Patents	听	听	290	听
听	听	听		听
Total intangible assets	听	听	10,290	听
Goodwill	听	听	828	听
Accounts payable and accrued expenses	听	听	(54	)
Contingent consideration	听	听	(580	)
听	听	听		听
Total purchase price	听	$	10,543	听
听	听	听		听

听听听听听We believe the estimated fair values assigned to the CURNA assets acquired and liabilities assumed are based on reasonable assumptions. However, the fair value estimates for the purchase price allocation may change during the allowable allocation period, which is up to one year from the acquisition date, if additional information becomes available that would require changes to our estimates.

听听听听听Exakta-小猪视频app acquisition

听听听听听In February听2010, we acquired Exakta-小猪视频app (previously known as Pharmacos Exakta S.A. de C.V.), a privately-owned Mexican company engaged in the manufacture, marketing and distribution of ophthalmic and other pharmaceutical products for government and private markets since 1957. Pursuant to a purchase agreement we acquired all of the outstanding stock of Exakta-小猪视频app and real property owned by an affiliate of Exakta-小猪视频app for a total aggregate purchase price of $3.5听million, of which an aggregate of $1.5听million was paid in cash and $2.0听million was paid in shares of our Common Stock, par value $.01. In September听2010, we reduced the consideration paid by $0.1听million in working capital adjustments per the purchase agreement. The number of shares to be issued was determined by the average closing price of our Common Stock as reported on the NYSE Amex for the ten trading days ending on February听12, 2010. A total of 1,371,428 shares of our Common Stock were issued in the transaction which were valued at $2.0听million due to trading restrictions. A portion of the proceeds will remain in escrow for a period of time to satisfy indemnification claims.

听听听听听Investments

听听听听听In November听2010, we made an investment in Fabrus, LLC (聯Fabrus聰), a privately held early stage biotechnology company with next generation therapeutic antibody drug discovery and development capabilities. Fabrus is using its proprietary antibody screening and engineering approach to discover promising lead compounds against several important oncology targets. As of March听31, 2011, we hold approximately 13% of Fabrus聮 outstanding membership interests on a fully diluted basis. Our investment was part of a $2.1听million financing for Fabrus and included other related parties. Refer to Note 8.

听听听听听Effective September听21, 2009, we entered into an agreement pursuant to which we invested $2.5 million in cash in Cocrystal Discovery, Inc., a privately held biopharmaceutical company (聯Cocrystal聰). Cocrystal is focused on the discovery and development of novel antiviral drugs using a combination of protein structure-based approaches. As of March听31, 2011 we hold approximately 16% of Cocrystal on a fully diluted basis. Refer to Note 8.

听听听听听On June听10, 2009, we entered into a stock purchase agreement with Sorrento Therapeutics, Inc. (聯Sorrento聰), a publicly held company with a technology for generating fully human monoclonal antibodies, pursuant to which we invested $2.3听million in Sorrento. 小猪视频app owns approximately 59,015,257 shares of Sorrento Common Stock, or approximately 23% of Sorrento聮s total outstanding common stock at March听31, 2011. The closing stock price for Sorrento聮s common stock, a thinly traded stock, as quoted on the over-the-counter markets was $0.30 per share on March听31, 2011. Refer to Note 8.

听听听听听Rolapitant license

听听听听听In December听2010, we entered into a license agreement (the 聯TESARO License聰) with TESARO, Inc. (聯TESARO聰) granting TESARO exclusive rights to the development, manufacture, commercialization and distribution of rolapitant and a related compound. Under the terms of the TESARO License, we are eligible for payments of up to $121.0听million, including an up-front payment of $6.0听million, which was received in December听2010, and additional payments based upon achievement of specified regulatory and commercialization milestones. In addition, TESARO will pay us double digit tiered royalties on sales of licensed product. We will share future profits from the commercialization of licensed products in Japan with TESARO and we will have an option to market the products in Latin America. In connection with the TESARO License, we also acquired an equity position in TESARO. We recorded the equity position at $0.7听million, the estimated fair value based on a discounted cash flow model.

听听听听听In accounting for the license of rolapitant to TESARO, we determined that we did not have any continuing involvement in the development of rolapitant or any other future performance obligations and, as a result, recognized the $6.0听million up-front payment and the $0.7听million equity position as license revenue during the year ended December听31, 2010.

听听听听听Pursuant to an asset purchase agreement with Schering-Plough Corporation (聯Schering聰), we acquired rolapitant and other assets relating to Schering聮s neurokinin-1 (聯NK-1聰) receptor antagonist program on October听12, 2009 (the 聯Schering Agreement聰). Under the terms of the Schering Agreement, we paid Schering $2.0听million in cash upon closing and agreed to pay up to an additional $27.0听million upon certain development milestones. Rolapitant, the lead product in the NK-1 program, successfully completed Phase II clinical testing for prevention of nausea and vomiting related to cancer chemotherapy and surgery, and other indications. Development of rolapitant and the other assets had been stopped at the time of our acquisition and there were no ongoing clinical trials. We recorded $2.0听million as in-process research and development expense upon our acquisition.

听听听听听Variable interest entities

听听听听听We have determined that we hold variable interests (聯VIE聰) in three entities, TESARO, Fabrus and CoCrystal. We made this determination as a result of our assessment that they do not have sufficient resources to carry out their principal activities without additional subordinated financial support.

听听听听听In order to determine the primary beneficiary of Cocrystal and Fabrus, we evaluated our investment as well as our investment combined with a related party group to identify who had the most power to control each entity and who received the largest benefits (or absorbed the most losses) from each entity. The related party group when considering our investment in Cocrystal includes 小猪视频app and the Frost Group, LLC (the 聯Frost Group聰). The Frost Group members include Frost Gamma Investments Trust, of which Phillip Frost, MD, our Chairman of our Board of Directors and Chief Executive Officer, is the sole trustee (the 聯Gamma Trust聰), Dr.听Jane H. Hsiao, who is the Vice Chairman of the board of directors and Chief Technical Officer, Steven D. Rubin who is Executive Vice President 聴 Administration and a director of the Company and Rao Uppaluri who is the Chief Financial Officer of the Company. As of March听31, 2011 we own approximately 16% of Cocrystal and members of the Frost Group own approximately 42% of Cocrystal聮s voting stock on an as converted basis, including 39% held by the Gamma Trust. Dr.听Frost, Mr.听Rubin, and Dr.听Hsiao currently serve on the Board of Directors of Cocrystal and represent 50% of its board. The Gamma Trust can significantly influence Cocrystal through its board representation and voting power. As such, we have determined that the Gamma Trust is the primary beneficiary within the related party group.

听听听听听The related party group when considering our investment in Fabrus includes 小猪视频app and the Gamma Trust, Hsu Gamma Investment, L.P., of which Jane Hsiao is the general partner (聯Hsu Gamma聰), and the Richard Lerner Family Trust. Dr.聮s Frost, Hsiao and Lerner are all members of our Board of Directors. As of March听31, 2011, we own approximately 13% of Fabrus and Drs.听Frost, Hsiao and Lerner own 24% of Fabrus聮 voting stock on an as converted basis, including 16% held by the Gamma Trust. Drs.听Frost and Hsiao currently serve on the Board of Managers of Fabrus and represent 40% of its board. The Gamma Trust can significantly influence the success of Fabrus through its board representation and voting power. As such, we have determined that the Gamma Trust is the primary beneficiary within the related party group. Because we have the ability to exercise significant influence over Cocrystal聮s and Fabrus聮 operations through our related party affiliates, we account for our investments in Cocrystal and Fabrus, under the equity method.

听听听听听In order to determine the primary beneficiary of TESARO, we evaluated the power and benefits held by its equity holders. On an as converted basis, we hold an equity interest of approximately 6% of TESARO as of

March听31, 2011. The decrease in our ownership percentage on an as converted basis from 9% at December听31, 2010 is a result of TESARO issuing additional equity securities during the three months ended March听31, 2011. As of March听31, 2011, we determined that despite the issuance of additional equity securities, TESARO does not have sufficient resources to carry out its principal activities without additional subordinated financial support. In addition, we do not hold any seats on the Board of Directors and we do not have any management positions. The largest equity holder owns approximately 68% of TESARO on an as converted basis and is represented by two members of TESARO聮s board of directors. As a result of that equity holder having the power to influence TESARO and being entitled to the largest share of the benefits of TESARO, we determined such holder is the primary beneficiary of TESARO. Because we do not have the ability to exercise significant influence over TESARO聮s operations, we account for TESARO under the cost method of accounting.

听听听听听We have not provided financial or other support to the variable interest entities other than those associated with our original investments in Cocrystal and Fabrus or those associated with our TESARO License and we are not obligated to provide ongoing financial support to them.

听听听听听The following table reflects our maximum exposure to each of our investments:

听	听	听	听	听	听	听	听	听
Investee name	听	(in thousands)		听	听	Accounting method		听
听
Sorrento	听	$	2,300	听	听	Equity method
Cocrystal	听	听	2,500	听	听	VIE, equity method
Fabrus	听	听	650	听	听	VIE, equity method
TESARO	听	听	731	听	听	VIE, cost method
Less accumulated losses in investees	听	听	(1,490	)	听	听	听	听
听	听	听		听	听	听	听	听
Total	听	$	4,691	听	听	听	听	听
听	听	听		听	听	听	听	听

NOTE 6 FAIR VALUE MEASUREMENTS

听听听听听We record fair value at an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. We utilize a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value. These tiers include: Level 1, defined as observable inputs such as quoted prices in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring an entity to develop its own assumptions.

听听听听听As of March听31, 2011, we held money market funds and treasury securities that qualify as cash equivalents, marketable securities that consist of treasury securities, forward contracts for inventory purchases (Refer to Note 7) and contingent consideration related to the acquisition of CURNA (Refer to Note 5) that are required to be measured at fair value on a recurring basis. As of March听31, 2011, we held money market funds and treasury securities totaling $46.9听million, including treasury securities maturing June听9, 2011 and June听23, 2011, that qualify as cash equivalents as well as marketable securities which were comprised entirely of treasury securities totaling $60.0听million, maturing June听30, 2011, July听14, 2011, and July听21, 2011, that are required to be measured at fair value on a recurring basis. The $85.0听million of treasury securities are recorded at amortized cost, which reflects their approximate fair value. Our other assets and liabilities carrying value approximate their fair value due to their short-term nature.

听听听听听Any future fluctuation in fair value related to these instruments that is judged to be temporary, including any recoveries of previous write-downs, would be recorded in accumulated other comprehensive income or loss. If we determine that any future valuation adjustment was other-than-temporary, we would record a charge to the consolidated statement of operations as appropriate.

听听听听听Our financial assets and liabilities measured at fair value on a recurring basis are as follows:

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Fair value measurements as of March 31, 2011

听

听

听

Quoted prices

听

听

听

听

听

听

听

听

听

听

听

听

in active

听

听

Significant

听

听

听

听

听

听

听

听

听

markets for

听

听

other

听

听

Significant

听

听

听

听

听

听

identical

听

听

observable

听

听

unobservable

听

听

听

听

听

听

assets

听

听

inputs

听

听

inputs

听

听

听

听

(in thousands)

听

(Level 1)

听

听

(Level 2)

听

听

(Level 3)

听

听

Total

听

Assets:

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Money market funds

听

$

21,944

听

听

$

聴

听

听

$

聴

听

听

$

21,944

听

Treasury securities

听

听

84,979

听

听

听

聴

听

听

听

聴

听

听

听

84,979

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Total assets

听

$

106,923

听

听

$

聴

听

听

$

聴

听

听

$

106,923

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Liabilities:

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Forward contracts

听

$

聴

听

听

$

340

听

听

$

聴

听

听

$

340

听

CURNA contingent considerations

听

听

聴

听

听

听

聴

听

听

听

580

听

听

听

580

听

听

听

听

听

听

听

听

听

听

听

听

听

听

Total liabilities

听

$

聴

听

听

$

340

听

听

$

580

听

听

$

920

听

听

听

听

听

听

听

听

听

听

听

听

听

听

NOTE 7 DERIVATIVE CONTRACTS

听听听听听We enter into foreign currency forward exchange contracts to cover the risk of exposure to exchange rate differences arising from inventory purchases on letters of credit. Under these forward contracts, for any rate above or below the fixed rate, we receive or pay the difference between the spot rate and the fixed rate for the given amount at the settlement date.

听听听听听We record derivative financial instruments on our balance sheet at their fair value as an accrued expense and the changes in the fair value are recognized in income in other expense net when they occur, the only exception being derivatives that qualify as hedges. To qualify the derivative instrument as a hedge, we are required to meet strict hedge effectiveness and contemporaneous documentation requirements at the initiation of the hedge and assess the hedge effectiveness on an ongoing basis over the life of the hedge. At March听31, 2011, the forward contracts did not meet the documentation requirements to be designated as hedges. Accordingly, we recognize all changes in fair values in income.

听听听听听The outstanding contracts at March听31, 2011, have been recorded at fair value, and their maturity details are as follows:

听

听

听

听

听

听

听

听

听

听

听

听

听

(in thousands)

听

听

听

听

听

Fair value at

听

听

Effect on gain

听

Days until maturity

听

Contract value

听

听

March 31, 2011

听

听

(loss)

听

0 to 30

听

$

1,722

听

听

$

1,912

听

听

$

(190

)

31 to 60

听

听

1,177

听

听

听

1,233

听

听

听

(56

)

61 to 90

听

听

784

听

听

听

866

听

听

听

(82

)

91 to 120

听

听

聴

听

听

听

聴

听

听

听

聴

听

121 to 180

听

听

186

听

听

听

191

听

听

听

(5

)

More than 180

听

听

193

听

听

听

200

听

听

听

(7

)

听

听

听

听

听

听

听

听

听

听

Total

听

$

4,062

听

听

$

4,402

听

听

$

(340

)

听

听

听

听

听

听

听

听

听

听

NOTE 8 RELATED PARTY TRANSACTIONS

听听听听听On March听14, 2011, we issued 27,000,000 shares of our Common Stock. Refer to Note 11. The 27,000,000 shares of our Common Stock issued include an aggregate of 3,733,000 shares of our Common Stock purchased by the Gamma Trust and Hsu Gamma at the public offering price. The Gamma Trust purchased an aggregate of 3,200,000 shares for approximately $12听million, and Hsu Gamma purchased an aggregate of 533,000 shares for approximately $1.9听million. Jefferies & Company, Inc. and J.P. Morgan Securities LLC acted as joint book-running managers for the offering. UBS Investment Bank and Lazard Capital Markets LLC acted as co-lead managers for

the offering and Ladenburg Thalmann & Co. Inc., a subsidiary of Ladenburg Thalmann Financial Services Inc., acted as co-manager for the offering. Dr.听Frost is the Chairman of the Board of Directors and principal shareholder of Ladenburg Thalmann Financial Services Inc.

听听听听听On January听28, 2011, we entered into a definitive agreement with CURNA and each of CURNA聮s stockholders and optionholders, pursuant to which we agreed to acquire all of the outstanding stock of CURNA in exchange for $10.0听million in cash, plus $0.6听million in liabilities, of which $0.5听million was paid at closing. At the time of the transaction, The Scripps Research Institute (聯TSRI聰) owned approximately 4% of CURNA. Dr.听Frost serves as Trustee for TSRI and Richard Lerner is its President.

听听听听听We have a $12.0听million line of credit with the Frost Group. On June听2, 2010 we repaid all amounts outstanding on the line of credit including $12听million in principal and $4.1听million in interest. The line of credit, which previously expired on January听11, 2011, was renewed on February听22, 2011 until March听31, 2012 on substantially the same terms as those in effect at the time of expiration. We have the ability to draw funds under the line of credit until its expiration in March听2012. We are obligated to pay interest upon maturity, capitalized quarterly, on outstanding borrowings under the line of credit at an 11% annual rate. The line of credit is collateralized by all of our U.S. personal property except our intellectual property.

听听听听听In November听2010, we made an investment in Fabrus, a privately held early stage biotechnology company with next generation therapeutic antibody drug discovery and development capabilities. In exchange for the investment, we acquired approximately 13% of Fabrus聮 outstanding membership interests on a fully diluted basis. Our investment was part of a $2.1听million financing for Fabrus. Other investors participating in the financing include the Gamma Trust and Hsu Gamma. In connection with the financing, Drs.听Frost and Hsiao joined the Fabrus Board of Managers. Dr. Richard Lerner, a director of the Company, owns approximately 5% of Fabrus. Vaughn Smider, Founder and CEO of Fabrus, is an Assistant Professor at TSRI. Dr.听Frost serves as a Trustee for TSRI, and Richard Lerner serves as its President.

听听听听听On July听20, 2010, we entered into a use agreement with TRSI for approximately 1,100 square feet of space in Jupiter, Florida to house our molecular diagnostics operations. Dr.听Frost serves as a trustee for TSRI and Richard Lerner serves as its president. Pursuant to the terms of the use agreement, which is effective as of November听1, 2009, gross rent is approximately $40 thousand per year for a two-year term which may be extended upon mutual agreement for one additional year.

听听听听听On June听1, 2010, the Company entered into a cooperative research and development agreement with Academia Sinica in Taipei, Taiwan (聯Academia Sinica聰), for pre-clinical work for a compound against various forms of cancer. Dr.听Alice Yu, a member of our board of directors, is a Distinguished Research Fellow and Associate Director at the Genomics Research Center, Academia Sinica (聯Genomics Research Center聰). In connection with the agreement, we are required to pay Academia Sinica approximately $0.2听million over the term of the agreement.

听听听听听Effective March听5, 2010, the Frost Group assigned two license agreements with Academia Sinica to the Company. The license agreements pertain to alpha-galactosyl ceramide analogs and their use as immunotherapies and peptide ligands in the diagnosis and treatment of cancer. In connection with the assignment of the two licenses, the Company agreed to reimburse the Frost Group for the licensing fees previously paid by the Frost Group to Academia Sinica in the amounts of $50 thousand and $75 thousand, respectively, as well as reimbursement of certain expenses of $50 thousand.

听听听听听Effective September听21, 2009, we entered into an agreement pursuant to which we invested $2.5 million in Cocrystal in exchange for 1,701,723 shares of Cocrystal聮s Convertible Series听A Preferred Stock. A group of investors, led by the Frost Group (the 聯CoCrystal Investors聰), previously invested $5听million in Cocrystal, and agreed to invest an additional $5听million payable in two equal installments in September听2009 and March听2010. As a result of an amendment to the CoCrystal Investors agreements dated June听9, 2009, 小猪视频app, rather than the CoCrystal Investors, made the first installment investment ($2.5听million) on September听21, 2009. Refer to Note 5.

听听听听听On July听20, 2009, we entered into a worldwide exclusive license agreement with Academia Sinica in Taipei, Taiwan, for a new technology to develop protein vaccines against influenza and other viral infections. Dr.听Alice Yu, a member of our board of directors, is a Distinguished Research Fellow and Associate Director at the Genomics Research Center. In connection with the license, the Company paid to Academia Sinica an upfront licensing fee and agreed to pay royalties and other payments on the occurrence of certain development milestones.

听听听听听On June听16, 2009, we entered into an agreement to lease approximately 10,000 square feet of space in Hialeah, Florida to house manufacturing and service operations for our ophthalmic instrumentation business (the 聯Hialeah Facility聰) from an entity controlled by Dr.听Frost and Dr. Jane Hsiao. Pursuant to the terms of a lease agreement, which is effective as of February听1, 2009, gross rent is $0.1听million per year for a one-year lease and was extended through February听1, 2011.

听听听听听On June听10, 2009, we entered into a stock purchase agreement with Sorrento, pursuant to which we invested $2.3听million in Sorrento. Refer to Note 5. In exchange for the investment, we acquired approximately one-third of the outstanding common shares of Sorrento and received a fully-paid, exclusive license to the Sorrento antibody library for the discovery and development of therapeutic antibodies in the field of ophthalmology. On September听21, 2009, Sorrento entered into a merger transaction with Quikbyte Software, Inc. Prior to the merger transaction, certain investors, including Dr.听Frost and other members of 小猪视频app management, made an investment in Quikbyte. Dr.听Richard Lerner, a member of our Board of Directors, serves as a consultant and scientific advisory board member to Sorrento and owns less than one percent of its shares.

听听听听听In November听2007, we entered into an office lease with Frost Real Estate Holdings, LLC, an entity affiliated with Dr.听Frost. The lease is for approximately 8,300 square feet of space in an office building in Miami, Florida, where the Company聮s principal executive offices are located. The lease provides for payments of approximately $18 thousand per month in the first year increasing annually to $24 thousand per month in the fifth year, plus applicable sales tax. The rent is inclusive of operating expenses, property taxes and parking. The rent for the first year was reduced to reflect a $30 thousand credit for the costs of tenant improvements.

听听听听听On September听19, 2007, we entered into an exclusive technology license agreement with Winston Laboratories, Inc. (聯Winston聰). On February听23, 2010, we provided Winston notice of termination of the license agreement, and the agreement terminated on May听24, 2010. Previously, members of the Frost Group beneficially owned approximately 30% of Winston Pharmaceuticals, Inc., and Dr. Uppaluri, our Chief Financial Officer, served as a member of Winston聮s board. Effective May听19, 2010, the members of the Frost Group sold 100% of Winston聮s capital stock beneficially owned by them (consisting of an aggregate of 18,399,271 outstanding shares of common stock and warrants to purchase an aggregate of 8,958,975 shares of common stock) to an entity whose members include Dr. Joel E. Bernstein, the President and Chief Executive Officer of Winston. As consideration for the sale, the Frost Group members received an aggregate of $789,500 in cash and non-recourse promissory notes in the aggregate principal amount of $10,263,500. Dr.听Uppaluri resigned from the Winston board effective May听19, 2010. In connection with the license agreement, we reimbursed Winston $29 thousand, and $3 thousand in the years ended December听31, 2009 and 2008, respectively, for services provided by Winston personnel to assist us with the clinical program for the product we licensed.

听听听听听We reimburse Dr.听Frost for Company-related use by Dr.听Frost and our other executives of an airplane owned by a company that is beneficially owned by Dr.听Frost. We reimburse Dr.听Frost in an amount equal to the cost of a first class airline ticket between the travel cities for each executive, including Dr.听Frost, traveling on the airplane for Company-related business. We do not reimburse Dr.听Frost for personal use of the airplane by Dr.听Frost or any other executive; nor do we pay for any other fixed or variable operating costs of the airplane. For the three months ended March听31, 2011 and 2010, we reimbursed Dr.听Frost approximately $57 thousand and $18 thousand, respectively, for Company-related travel by Dr.听Frost and other 小猪视频app executives.

NOTE 9 COMMITMENTS AND CONTINGENCIES

听听听听听In connection with our acquisition of CURNA, we agreed to pay a portion of future consideration to the CURNA sellers if we license or partner the CURNA technology with a third party including, license fees, upfront payments, royalties and milestone payments. As a result, we recorded $0.6听million, as contingent consideration for the future consideration. Refer to Note 5.

听听听听听On January听7, 2010, we received a letter from counsel to Nidek Co., Ltd. (聯Nidek聰) alleging that Ophthalmic Technologies, Inc. (聯OTI聰) or 小猪视频app breached its service obligations to Nidek under the Service Agreement between OTI, Nidek and Newport Corporation, dated December听29, 2006, and the Service Agreement by and between Nidek and OTI, dated the same date. We entered into a settlement agreement in April听2011 which resolved all disputes between the Company and Nidek and released us from any future service obligation to Nidek. The settlement did not have a material impact on our results of operations or financial condition.

听听听听听On May听6, 2008, we completed the acquisition of Vidus Ocular, Inc. (聯Vidus聰). Pursuant to a Securities Purchase Agreement with Vidus, each of its stockholders, and the holders of convertible promissory notes issued by

Vidus, we acquired all of the outstanding stock and convertible debt of Vidus in exchange for (i)听the issuance and delivery at closing of 658,080 shares of our Common Stock (the 聯Closing Shares聰); (ii)听the issuance of 488,420 shares of our Common Stock to be held in escrow pending the occurrence of certain development milestones (the 聯Milestone Shares聰); and (iii)听the issuance of options to acquire 200,000 shares of our Common Stock. Additionally, in the event that the stock price for our Common Stock at the time of receipt of approval or clearance by the U.S. Food & Drug Administration of a pre-market notification 510(k) relating to the Aquashunt聶 is not at or above a specified price, we will be obligated to issue an additional 413,850 shares of our Common Stock.

听听听听听We are a party to other litigation in the ordinary course of business. We do not believe that any such litigation will have a material adverse effect on our business, financial condition, or results of operations.

NOTE 10 SEGMENTS

听听听听听We currently manage our operations in two reportable segments, pharmaceutical and instrumentation segments. The pharmaceutical segment consists of two operating segments, our (i) pharmaceutical research and development segment which is focused on the research and development of pharmaceutical products, diagnostic tests and vaccines, and (ii)听the pharmaceutical operations we acquired in Chile and Mexico through the acquisition of 小猪视频app Chile and Exakta-小猪视频app. The instrumentation segment consists of ophthalmic instrumentation products and the activities related to the research, development, manufacture and commercialization of those products. There are no inter-segment sales. We evaluate the performance of each segment based on operating profit or loss. There is no inter-segment allocation of interest expense and income taxes.

听听听听听Information regarding our operations and assets for the two segments and the unallocated corporate operations as well as geographic information are as follows:

听	听	听	听	听	听	听	听	听
听	听	For the three months ended						听
听	听	March 31,						听
(in thousands)	听	2011		听	听	2010		听
Product sales	听	听	听	听	听	听	听	听
Pharmaceutical	听	$	6,937	听	听	$	5,312	听
Instrumentation	听	听	1,698	听	听	听	2,610	听
听	听	听		听	听	听		听
听	听	$	8,635	听	听	$	7,922	听
听	听	听		听	听	听		听
Operating loss	听	听	听	听	听	听	听	听
Pharmaceutical	听	$	(1,019	)	听	$	(644	)
Instrumentation	听	听	(955	)	听	听	(936	)
Corporate	听	听	(3,112	)	听	听	(2,486	)
听	听	听		听	听	听		听
听	听	$	(5,086	)	听	$	(4,066	)
听	听	听		听	听	听		听
Depreciation and amortization	听	听	听	听	听	听	听	听
Pharmaceutical	听	$	824	听	听	$	514	听
Instrumentation	听	听	130	听	听	听	444	听
Corporate	听	听	43	听	听	听	13	听
听	听	听		听	听	听		听
听	听	$	997	听	听	$	971	听
听	听	听		听	听	听		听
Product sales	听	听	听	听	听	听	听	听
United States	听	$	264	听	听	$	197	听
Chile	听	听	5,756	听	听	听	4,937	听
Mexico	听	听	1,199	听	听	听	401	听
All others	听	听	1,416	听	听	听	2,387	听
听	听	听		听	听	听		听
听	听	$	8,635	听	听	$	7,922	听
听	听	听		听	听	听		听

听	听	听	听	听	听	听	听	听
听	听	As of						听
听	听	March 31,		听	听	December		听
听	听	2011		听	听	31, 2010		听
Assets	听	听	听	听	听	听	听	听
Pharmaceutical	听	$	59,503	听	听	$	51,599	听
Instrumentation	听	听	9,126	听	听	听	8,637	听
Corporate	听	听	107,678	听	听	听	17,610	听
听	听	听		听	听	听		听
听	听	$	176,307	听	听	$	77,846	听
听	听	听		听	听	听		听

听听听听听During the three months ended March听31, 2011, our largest customer represented 12% of our total revenue. During the three months ended March听31, 2010, our two largest customers represented 17%, and 10%, respectively, of our revenue. As of March听31, 2011, one customer represented 30% of our accounts receivable balance. As of December听31, 2010, two customers represented 32% and 11%, respectively, of our accounts receivable balance.

NOTE 11 ISSUANCE OF COMMON STOCK

听听听听听On March听14, 2011, we issued 27,000,000 shares of our Common Stock in a public offering at a price of $3.75 per share. We also granted the underwriters a 30-day option to purchase up to an additional 4,050,000 shares of our Common Stock to cover overallotments, if any. On March听15, 2011, representatives for the underwriters provided us notice that the underwriters exercised a portion of their 4,050,000 share over-allotment option for 2,397,029 additional shares of our Common Stock.

The following table reflects the proceeds received from the issuance of shares:

听	听	听	听	听	听	听	听	听
(in thousands, except share amounts)	听	Shares		听	听	Dollars		听
Original issuance	听	听	27,000,000	听	听	$	101,250	听
Over-allotment	听	听	2,397,029	听	听	听	8,989	听
听	听	听		听	听	听		听
Total	听	听	29,397,029	听	听	听	110,239	听
听	听	听		听	听	听	听	听
Underwriters discount and commissions(1)	听	5.5% on 24,064,029 shares			听	听	(4,963	)
Offering expenses	听	听	听	听	听	听	(448	)
听	听	听	听	听	听	听		听
Net proceeds	听	听	听	听	听	$	104,828	听
听	听	听	听	听	听	听		听

NOTE 12 SUBSEQUENT EVENTS

听听听听听On or about May听3, 2011, we initiated the redemption of our Series听A Preferred Stock. Holders of our Series听A Preferred Stock have until May听30, 2011 to elect to convert their Series听A Preferred Shares into shares of our Common Stock, which convert on a 1:1 basis. The closing price of our Common Stock on May听2, 2011 was $3.91. On June听3, 2011, we will redeem all of our outstanding Series听A Preferred Stock for their redemption amount of $2.50, plus unpaid accrued dividends of $0.35 per share. As of March听31, 2011 there were 722,700 shares of our Series听A Preferred Stock outstanding, resulting in a potential cash payment of approximately $2.1听million if all of the Series听A Preferred Stock remain outstanding as of June听3, 2011.

听听听听听We have reviewed all subsequent events and transactions that occurred after the date of our March听31, 2011 consolidated balance sheet date, through the time of filing this Quarterly Report on Form 10-Q.

Item听2. Management聮s Discussion and Analysis of Financial Condition and Results of Operations

OVERVIEW

听听听听听You should read this discussion together with the condensed consolidated financial statements, related Notes, and other financial information included elsewhere in this report and in our Annual Report on Form 10-K for the year ended December听31, 2010 (the 聯Form听10-K聰). The following discussion contains assumptions, estimates and other forward-looking statements that involve a number of risks and uncertainties, including those discussed under 聯Risk Factors,聰 in Part听II, Item 1A of our Form 10-K for the year ended December听31, 2010. These risks could cause our actual results to differ materially from those anticipated in these forward-looking statements.

听听听听听We are a multi-national pharmaceutical and diagnostics company that seeks to establish industry-leading positions in large and rapidly growing medical markets by leveraging our discovery, development and commercialization expertise and our novel and proprietary technologies. Our current focus is on conditions with major unmet medical needs including neurological disorders, infectious diseases, oncology and ophthalmologic diseases. We are developing a range of solutions to diagnose, treat and prevent these conditions, including molecular diagnostics tests, proprietary pharmaceuticals and vaccines. We plan to commercialize these solutions on a global basis in large and high growth markets, including emerging markets. We have already established emerging markets pharmaceutical platforms in Chile and Mexico, which are delivering revenue and which we expect to deliver cash flow and facilitate future market entry for our products currently in development. We also actively explore opportunities to acquire complementary pharmaceuticals, compounds, technologies, and businesses.

听听听听听We expect to incur substantial losses as we continue the development of our product candidates, continue our other research and development activities, and establish a sales and marketing infrastructure in anticipation of the commercialization of our diagnostic and pharmaceutical product candidates. We currently have limited commercialization capabilities, and it is possible that we may never successfully commercialize any of our diagnostic and pharmaceutical product candidates. We do not currently generate revenue from any of our diagnostic and pharmaceutical product candidates. Our research and development activities are budgeted to expand over a period of time and will require further resources if we are to be successful. As a result, we believe that our operating losses are likely to be substantial over the next several years. We may need to obtain additional funds to further develop our research and development programs, and there can be no assurance that additional capital will be available to us when needed on acceptable terms, or at all.

RECENT DEVELOPMENTS

听听听听听On March听14, 2011, we issued 27,000,000 shares of our Common Stock in a public offering at a price of $3.75 per share. We also granted the underwriters a 30-day option to purchase up to an additional 4,050,000 shares of our Common Stock to cover overallotments, if any. On March听15, 2011, representatives for the underwriters provided us notice that the underwriters exercised a portion of their 4,050,000 share over-allotment option for 2,397,029 additional shares of our Common Stock. We received approximately $104.8听million in net proceeds from the issuance of 29,397,029 shares of our Common Stock after deducting the underwriters聮 discounts and commissions and other estimated offering expenses.

听听听听听On January听31, 2011, we acquired all of the outstanding stock of CURNA, Inc. (聯CURNA聰), a privately held therapeutics company, in exchange for $10.0听million in cash, plus $0.6听million in liabilities, of which, $0.5听million was paid at closing. In addition to the cash consideration, we have agreed to pay to the CURNA sellers a portion of any consideration we receive in connection with certain license, partnership or collaboration agreements we may enter into with third parties in the future relating to the CURNA technology, including, license fees, upfront payments, royalties and milestone payments. CURNA is engaged in the discovery of new drugs for the treatment of a wide variety of illnesses, including cancer, heart disease, metabolic disorders and a range of genetic anomalies.

RESULTS OF OPERATIONS

FOR THE THREE MONTHS ENDED MARCH 31, 2011 AND 2010

听听听听听Revenue. Revenue for the three months ended March听31, 2011, was $8.6听million, compared to $7.9听million for the comparable 2010 period. The increase in revenue during the first three months of 2011 is primarily due to revenue from our 小猪视频app Chile and Exakta-小猪视频app pharmaceutical businesses. We acquired Exakta-小猪视频app in February听2010, and as a result, the 2010 period reflects revenue only after the acquisition occurred. Revenue from

our instrumentation business decreased from the 2010 period, primarily as a result of decreased demand from our international customers for our OCT/SLO product.

听听听听听Gross margin. Gross margin for the three months ended March听31, 2011, was $3.0听million compared to $2.4听million for the comparable period of 2010. Gross margin for the three months ended March听31, 2011, increased from the 2010 period primarily as a result of the increased gross margin generated by our pharmaceutical businesses in Chile and Mexico, partially offset by decreased revenue and resulting decreased gross margin generated by our instrumentation business.

听听听听听Selling, general and administrative expense. Selling, general and administrative expense for the three months ended March听31, 2011, was $5.6听million compared to $4.2听million of expense for the comparable period of 2010. The increase in selling, general and administrative expenses is primarily the result of increased warehousing and distribution costs for our Chilean operations, increased equity based compensation expense and a full period of selling, general and administrative expenses for our operations in Mexico. Selling, general and administrative expenses during the first three months of 2011 and 2010 primarily include personnel expenses, including equity-based compensation expense of $1.4听million and $1.0听million, respectively, and professional fees.

听听听听听Research and development expense. Research and development expense during the three months ended March听31, 2011 and 2010, was $1.6听million and $1.3听million, respectively. The increase in research and development expense primarily is the result of increased personnel expenses including equity based compensation expense. The three months ended March听31, 2011 and 2010, include equity-based compensation expense of $0.4听million and $0.2听million, respectively. During the three months ended March听31, 2011, research and development expense primarily consisted of activities related to our molecular diagnostics development program, research and development expense for our instrumentation business including the development of next generation devices, and development of the technology acquired from CURNA. Research and development expense for the three month period ended March听31, 2010 primarily included activities related to our rolapitant development program, which we out licensed in December听2010, our molecular diagnostics development program and research and development activities for our instrumentation business.

听听听听听Other operating expenses. Other operating expenses was $0.9听million for the three months ended March听31, 2011 and March听31, 2010. Other operating expenses primarily include the amortization of intangible assets. Amortization expense during the three months ended March听31, 2011 includes the amortization expense of the CURNA intangible assets acquired in January听2011, offset by a portion of the OTI intangible assets that fully amortized in November听2010.

听听听听听Other income and expenses. Other income, net was $38 thousand for the first three months of 2011 compared to other expense, net of $0.3听million for the comparable 2010 period. Other income primarily consists of interest earned on our cash and cash equivalents and other expense primarily reflects the interest incurred on our line of credit with The Frost Group LLC (the 聯Frost Group聰). On June听2, 2010, we repaid all amounts outstanding on the Frost Group line of credit including $12.0 million in principal and $4.1听million in interest. The Frost Group members include a trust controlled by Dr.听Frost, who is the Company聮s Chief Executive Officer and Chairman of the board of directors, Dr.听Jane H. Hsiao, who is the Vice Chairman of the board of directors and Chief Technical Officer, Steven D. Rubin who is Executive Vice President 聴 Administration and a director of the Company and Rao Uppaluri who is the Chief Financial Officer of the Company.

听听听听听Income taxes. Our income tax provision reflects the income tax payable in Chile and Mexico. We have recorded a full valuation allowance against our deferred tax assets in the U.S.

LIQUIDITY AND CAPITAL RESOURCES

听听听听听At March听31, 2011, we had cash, cash equivalents and marketable securities of approximately $107.9听million. Cash used in operations during 2011 primarily reflects expenses related to research and development activities, selling, general and administrative activities related to our corporate and instrumentation operations, as well as our operations in Chile and Mexico. Since our inception, we have not generated sufficient gross margins to offset our operating and other expenses and our primary source of cash has been from the sale of our stock and credit facilities available to us.

听听听听听On March听14, 2011, we issued 27,000,000 shares of our Common Stock in a public offering at a price of $3.75 per share. We also granted the underwriters a 30-day option to purchase up to an additional 4,050,000 shares of our Common Stock to cover overallotments, if any. On March听15, 2011, representatives for the underwriters provided

us notice that the underwriters exercised a portion of their 4,050,000 share over-allotment option for 2,397,029 additional shares of our Common Stock. We received approximately $104.8听million, net, from the issuance of 29,397,029 shares of our Common Stock.

听听听听听On January听31, 2011, we acquired all of the outstanding stock of CURNA in exchange for $10.0 million in cash, plus $0.6听million in liabilities, of which, $0.5听million was paid at closing. In addition to the cash consideration, we have agreed to pay to the CURNA sellers a portion of any consideration we receive in connection with certain license, partnership or collaboration agreements we may enter into with third parties in the future relating to the CURNA technology, including, license fees, upfront payments, royalties and milestone payments. As a result, we recorded $0.6听million, as contingent consideration for the future consideration. CURNA is engaged in the discovery of new drugs for the treatment of a wide variety of illnesses, including cancer, heart disease, metabolic disorders and a range of genetic anomalies.

听听听听听We have outstanding lines of credit in the aggregate amount of $18.9听million with seven financial institutions in Chile, of which, $4.3听million is unused. These lines of credit are used primarily as a source of working capital and for inventory purchases. The average interest rate on these lines of credit is approximately 3%. These lines of credit are short term and are generally due within three months. The highest balance at any time during the three months ended March听31, 2011, was $14.8听million. We intend to continue to enter into these lines of credit as needed. There is no assurance that this or other funding sources will be available to us on acceptable terms, or at all.

听听听听听We currently have an unutilized $12.0听million line of credit with the Frost Group. The line of credit, which previously expired on January听11, 2011, was renewed on February听22, 2011 on substantially the same terms as those in effect at the time of expiration. We are obligated to pay interest upon maturity, capitalized quarterly, on outstanding borrowings under the line of credit at an 11% annual rate, which is due March听31, 2012. The line of credit is collateralized by all of our U.S. based personal property except our intellectual property.

听听听听听We expect to incur losses from operations for the foreseeable future. We expect to incur substantial research and development expenses, including expenses related to the hiring of personnel and additional clinical trials. We expect that selling, general and administrative expenses will also increase as we expand our sales, marketing and administrative staff and add infrastructure.

听听听听听We believe the cash, cash equivalents, and marketable securities on hand at March听31, 2011 and the amounts available to be borrowed under our lines of credit are sufficient to meet our anticipated cash requirements for operations and debt service beyond the next 12听months. We based this estimate on assumptions that may prove to be wrong or are subject to change, and we may be required to use our available cash resources sooner than we currently expect. If we acquire additional assets or companies, accelerate our product development programs or initiate additional clinical trials, we will need additional funds. Our future cash requirements will depend on a number of factors, including possible acquisitions, the continued progress of research and development of our product candidates, the timing and outcome of clinical trials and regulatory approvals, the costs involved in preparing, filing, prosecuting, maintaining, defending, and enforcing patent claims and other intellectual property rights, the status of competitive products, and our success in developing markets for our product candidates. If we are not able to secure additional funding when needed, we may have to delay, reduce the scope of, or eliminate one or more of our clinical trials or research and development programs.

听听听听听We intend to finance additional research and development projects, clinical trials and our future operations with a combination of available cash on hand, payments from potential strategic research and development, licensing and/or marketing arrangements, public offerings, private placements, debt financing and revenues from future product sales, if any. There can be no assurance, however, that additional capital will be available to us on acceptable terms, or at all.

CRITICAL ACCOUNTING POLICIES AND ESTIMATES

听听听听听Accounting Estimates. The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of sales and expenses during the reporting period. Actual results could differ from those estimates.

听听听听听Equity-based compensation. We recognize equity based compensation as an expense in our financial statements and that cost is measured at the fair value of the award and expensed over their vesting period. Equity-based compensation arrangements to non-employees are recorded at their fair value on the measurement date. We

estimate the grant-date fair value of our stock option grants using a valuation model known as the Black-Scholes-Merton formula or the 聯Black-Scholes Model聰 and allocate the resulting compensation expense over the corresponding requisite service period associated with each grant. The Black-Scholes Model requires the use of several variables to estimate the grant-date fair value of stock options including expected term, expected volatility, expected dividends and risk-free interest rate. We perform significant analyses to calculate and select the appropriate variable assumptions used in the Black-Scholes Model. We also perform significant analyses to estimate forfeitures of equity-based awards. We are required to adjust our forfeiture estimates on at least an annual basis based on the number of share-based awards that ultimately vest. The selection of assumptions and estimated forfeiture rates is subject to significant judgment and future changes to our assumptions and estimates may have a material impact on our Consolidated Financial Statements.

听听听听听Goodwill and intangible assets. The allocation of the purchase price for acquisitions requires extensive use of accounting estimates and judgments to allocate the purchase price to the identifiable tangible and intangible assets acquired, including in-process research and development, and liabilities assumed based on their respective fair values. Additionally, we must determine whether an acquired entity is considered to be a business or a set of net assets, because a portion of the purchase price can only be allocated to goodwill in a business combination.

听听听听听Appraisals inherently require significant estimates and assumptions, including but not limited to, determining the timing and estimated costs to complete the in-process research and development projects, projecting regulatory approvals, estimating future cash flows, and developing appropriate discount rates. We believe the estimated fair values assigned to the CURNA assets acquired and liabilities assumed are based on reasonable assumptions. However, the fair value estimates for the purchase price allocation may change during the allowable allocation period, which is up to one year from the acquisition date, if additional information becomes available that would require changes to our estimates.

听听听听听Allowance for doubtful accounts and revenue recognition. Generally, we recognize revenue from product sales when goods are shipped and title and risk of loss transfer to our customers. Certain of our products are sold directly to end-users and require that we deliver, install and train the staff at the end-users聮 facility. As a result, we do not recognize revenue until the product is delivered, installed and training has occurred. Return policies in certain international markets for our medical device products provide for stringent guidelines in accordance with the terms of contractual agreements with customers. Our estimates for sales returns are based upon the historical patterns of products returned matched against the sales from which they originated, and management聮s evaluation of specific factors that may increase the risk of product returns. We analyze accounts receivable and historical bad debt levels, customer credit worthiness and current economic trends when evaluating the adequacy of the allowance for doubtful accounts using the specific identification method. Our reported net loss is directly affected by management聮s estimate of the collectability of accounts receivable. The allowance for doubtful accounts recognized in our consolidated balance sheets at March听31, 2011 and December听31, 2010 was $1.2听million and $1.2听million, respectively.

听听听听听Recent accounting pronouncements. In December听2010, the FASB issued an amendment to the disclosure of supplementary pro forma information for business combinations. The amendment specifies that if a public entity presents comparative financial statements, the entity should disclose revenue and earnings of the combined entity as though the business combination(s) that occurred during the current year had occurred as of the beginning of the comparable prior annual reporting period only. The amendment also expands the supplemental pro forma disclosures under current accounting guidance to include a description of the nature and amount of material, nonrecurring pro forma adjustments directly attributable to the business combination included in the reported pro forma revenue and earnings. The amendment is effective prospectively for business combinations for which the acquisition date is on or after the beginning of the first annual reporting period beginning on or after December听15, 2010. The adoption of this amendment did not have a material impact on our financial statement disclosures.

听听听听听In December听2010, the FASB issued an amendment to the accounting for goodwill impairment tests. The amendment modifies Step 1 of the impairment test for reporting units with zero or negative carrying amounts. For those reporting units, an entity is required to perform Step 2 of the goodwill impairment test if it is more likely than not that a goodwill impairment exists. In determining whether it is more likely than not that a goodwill impairment exists, an entity should consider whether there are any adverse qualitative factors indicating that an impairment may exist. The qualitative factors are consistent with the existing guidance. The amendment is effective for fiscal years, and interim periods within those years, beginning after December听15, 2010. The adoption of this amendment did not have a material impact on our results of operations or financial condition.

听听听听听In December听2010, the FASB issued an amendment to the accounting for annual excise taxes paid to the federal government by pharmaceutical manufacturers under health care reform. The liability for the fee should be estimated and recorded in full upon the first qualifying branded prescription drug sale with a corresponding deferred cost that is amortized to expense using a straight-line method of allocation unless another method better allocates the fee over the calendar year that it is payable. The amendment is effective for calendar years beginning after December听31, 2010, when the fee initially becomes effective. As we currently do not manufacture pharmaceutical products in the United States, we do not expect the adoption of this amendment to have a material impact on our results of operations or financial condition.

听听听听听In March听2010, the FASB reached a consensus to issue an amendment to the accounting for revenue arrangements under which a vendor satisfies its performance obligations to a customer over a period of time, when the deliverable or unit of accounting is not within the scope of other authoritative literature, and when the arrangement consideration is contingent upon the achievement of a milestone. The amendment defines a milestone and clarifies whether an entity may recognize consideration earned from the achievement of a milestone in the period in which the milestone is achieved. This amendment is effective for fiscal years beginning on or after June听15, 2010, with early adoption permitted. We adopted this amendment prospectively for milestones achieved after January听1, 2011. This amendment did not have a material impact on our results of operation or financial condition.

听听听听听In October听2009, the FASB issued an amendment to the accounting for multiple-deliverable revenue arrangements. This amendment provides guidance on whether multiple deliverables exist, how the arrangements should be separated, and how the consideration paid should be allocated. As a result of this amendment, entities may be able to separate multiple-deliverable arrangements in more circumstances than under existing accounting guidance. This guidance amends the requirement to establish the fair value of undelivered products and services based on objective evidence and instead provides for separate revenue recognition based upon management聮s best estimate of the selling price for an undelivered item when there is no other means to determine the fair value of that undelivered item. The existing guidance previously required that the fair value of the undelivered item reflect the price of the item either sold in a separate transaction between unrelated third parties or the price charged for each item when the item is sold separately by the vendor. If the fair value of all of the elements in the arrangement was not determinable, then revenue was deferred until all of the items were delivered or fair value was determined. We adopted this amendment prospectively for revenue arrangements entered into or materially modified after January听1, 2011. This amendment did not have a material impact on our results of operation or financial condition.

Item听3. Quantitative and Qualitative Disclosures About Market Risk

听听听听听In the normal course of doing business, we are exposed to the risks associated with foreign currency exchange rates and changes in interest rates.

听听听听听Foreign Currency Exchange Rate Risk 聴 Although we do not speculate in the foreign exchange market, we may from time to time manage exposures that arise in the normal course of business related to fluctuations in foreign currency exchange rates by entering into offsetting positions through the use of foreign exchange forward contracts. Certain firmly committed transactions are hedged with foreign exchange forward contracts. As exchange rates change, gains and losses on the exposed transactions are partially offset by gains and losses related to the hedging contracts. Both the exposed transactions and the hedging contracts are translated at current spot rates, with gains and losses included in earnings.

听听听听听Our derivative activities, which consist of foreign exchange forward contracts, are initiated to hedge forecasted cash flows that are exposed to foreign currency risk. The foreign exchange forward contracts generally require us to exchange local currencies for foreign currencies based on pre-established exchange rates at the contracts聮 maturity dates. As exchange rates change, gains and losses on these contracts are generated based on the change in the exchange rates that are recognized in the consolidated statement of operations at maturity, and offset the impact of the change in exchange rates on the foreign currency cash flows that are hedged. If the counterparties to the exchange contracts do not fulfill their obligations to deliver the contracted currencies, we could be at risk for currency related fluctuations. We enter into these contracts with counterparties that we believe to be creditworthy and do not enter into any leveraged derivative transactions. We had $4.1听million in foreign exchange forward contracts outstanding at March听31, 2011, primarily to hedge Chilean-based operating cash flows against US dollars. If Chilean Pesos were to strengthen in relation to the US dollar, our hedged foreign currency cash-flows expense would be offset by a loss on the derivative contracts, with a net effect of zero.

听听听听听We do not engage in trading market risk sensitive instruments or purchasing hedging instruments or 聯other than trading聰 instruments that are likely to expose us to significant market risk, whether interest rate, foreign currency exchange, commodity price or equity price risk.

听听听听听Interest Rate Risk 聴 Our exposure to market risk relates to our cash and investments and to our borrowings. We maintain an investment portfolio of money market funds and treasury securities. The securities in our investment portfolio are not leveraged, and are, due to their very short-term nature, subject to minimal interest rate risk. We currently do not hedge interest rate exposure. Because of the short-term maturities of our investments, we do not believe that a change in market interest rates would have a significant negative impact on the value of our investment portfolio except for reduced income in a low interest rate environment. At March听31, 2011, we had cash, cash equivalents and marketable securities of $107.9听million. The weighted average interest rate related to our cash and cash equivalents for the three months ended March听31, 2011 was 0%. As of March听31, 2011, the principal value of our credit lines was $14.6听million, and have a weighted average interest rate of approximately 3%.

听听听听听The primary objective of our investment activities is to preserve principal while at the same time maximizing yields without significantly increasing risk. To achieve this objective, we invest our excess cash in debt instruments of the U.S. Government and its agencies, bank obligations, repurchase agreements and high-quality corporate issuers and money market funds that invest in such debt instruments, and, by policy, restrict our exposure to any single corporate issuer by imposing concentration limits. To minimize the exposure due to adverse shifts in interest rates, we maintain investments at an average maturity of generally less than one month.

Item听4. Controls and Procedures

听听听听听The Company聮s management, under the supervision and with the participation of the Company聮s Chief Executive Officer (聯CEO聰) and Chief Financial Officer (聯CFO聰), has evaluated the effectiveness of the Company聮s disclosure controls and procedures as defined in Securities and Exchange Commission (聯SEC聰) Rule听13a-15(e) as of March听31, 2011. Based on that evaluation, CEO and CFO have concluded that the Company聮s disclosure controls and procedures are effective to ensure that information the Company is required to disclose in reports that it files or submits under the Securities Exchange Act is accumulated and communicated to management, including the CEO and CFO, as appropriate, to allow timely decisions regarding required disclosure and is recorded, processed, summarized, and reported within the time periods specified in the SEC聮s rules and forms.

听听听听听There have been no changes to the Company聮s internal control over financial reporting that occurred during the Company聮s first quarter of 2011 that have materially affected, or are reasonably likely to materially affect, the Company聮s internal control over financial reporting.

PART II. OTHER INFORMATION

Item听1. Legal Proceedings

听听听听听We are a party to litigation in the ordinary course of business. We do not believe that any such litigation will have a material adverse effect on our business, financial condition or results of operations.

Item听1A. Risk Factors

听听听听听There have been no material changes from the risk factors as previously disclosed in the Item 1A of the Company Annual Report on Form 10-K.

Item听2. Unregistered Sales of Equity Securities and Use of Proceeds

听听听听听None.

Item听3. Defaults Upon Senior Securities

听听听听听None.

Item听4. (Removed and Reserved)

Item听5. Other Information

听听听听听None.

Item听6. Exhibits.

听	听	听
Exhibit听1.1(7)	听	Underwriting Agreement dated March听9, 2011, by and among 小猪视频app Health, Inc., Jefferies & Company, Inc. and J.P. Morgan Securities LLC, as representatives for the underwriters named therein.
听	听	听
Exhibit听2.1(1)	听	Merger Agreement and Plan of Reorganization, dated as of March听27, 2007, by and among Acuity Pharmaceuticals, Inc., Froptix Corporation, eXegenics, Inc., e-Acquisition Company I-A, LLC, and e-Acquisition Company II-B, LLC.
听	听	听
Exhibit听2.2(4)+	听	Securities Purchase Agreement dated May听6, 2008, among Vidus Ocular, Inc., 小猪视频app Instrumentation, LLC, 小猪视频app Health, Inc., and the individual sellers and noteholders named therein.
听	听	听
Exhibit听2.3(8)	听	Purchase Agreement, dated February听17, 2010, among Ignacio Levy Garc铆a and Jos茅 de Jes煤s Levy Garc铆a, Inmobiliaria Chapalita, S.A. de C.V., Pharmacos Exakta, S.A. de C.V., 小猪视频app Health, Inc., 小猪视频app Health Mexicana S. de R.L. de C.V., and 小猪视频app Manufacturing Facilities S. de R.L. de C.V.
听	听	听
Exhibit听2.4+	听	Agreement and Plan of Merger, dated January听28, 2011, among CURNA Inc., KUR, LLC, 小猪视频app Pharmaceuticals, LLC, 小猪视频app CURNA, LLC, and certain individuals named therein.
听	听	听
Exhibit听3.1(2)	听	Amended and Restated Certificate of Incorporation.
听	听	听
Exhibit听3.2(3)	听	Amended and Restated By-Laws.
听	听	听
Exhibit听4.1(1)	听	Form of Common Stock Warrant.
听	听	听
Exhibit听10.1	听	Amendment No.听2 to the Credit Agreement dated March 27, 2007, as amended, with the Frost Group, LLC.
听	听	听
Exhibit听10.2	听	Third Amended and Restated Subordinated Note and Security Agreement, dated February听22, 2011, with the Frost Group, LLC.
听	听	听
Exhibit听31.1	听	Certification by Phillip Frost, Chief Executive Officer, pursuant to Rule听13a-14(a) and 15d-14(a) of the Securities and Exchange Act of 1934 as adopted pursuant to Section听302 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.
听	听	听
Exhibit听31.2	听	Certification by Rao Uppaluri, Chief Financial Officer, pursuant to Rule听13a-14(a) and 15d-14(a) of the Securities and Exchange Act of 1934 as adopted pursuant to Section听302 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.

听	听	听
Exhibit听32.1	听	Certification by Phillip Frost, Chief Executive Officer pursuant to 18 U.S.C. Section听1350, as adopted pursuant to Section听906 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.
听	听	听
Exhibit听32.2	听	Certification by Rao Uppaluri, Chief Financial Officer pursuant to 18 U.S.C. Section听1350, as adopted pursuant to Section听906 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.

SIGNATURES

听听听听听Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Exhibit听Index

听	听	听
Exhibit Number	听	Description
Exhibit听2.4(+)	听	Agreement and Plan of Merger, dated January听28, 2011, among CURNA Inc., KUR, LLC, 小猪视频app Pharmaceuticals, LLC, 小猪视频app CURNA, LLC, and certain individuals named therein.
听	听	听
Exhibit听10.1	听	Amendment No.听2 to the Credit Agreement dated March听27, 2007, as amended, with the Frost Group, LLC.
听	听	听
Exhibit听10.2	听	Third Amended and Restated Subordinated Note and Security Agreement, dated February听22, 2011, with the Frost Group, LLC.
听	听	听
Exhibit听31.1	听	Certification by Phillip Frost, Chief Executive Officer, pursuant to Rule听13a-14(a) and 15d-14(a) of the Securities and Exchange Act of 1934 as adopted pursuant to Section听302 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.
听	听	听
Exhibit听31.2	听	Certification by Rao Uppaluri, Chief Financial Officer, pursuant to Rule听13a-14(a) and 15d-14(a) of the Securities and Exchange Act of 1934 as adopted pursuant to Section听302 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.
听	听	听
Exhibit听32.1	听	Certification by Phillip Frost, Chief Executive Officer pursuant to 18 U.S.C. Section听1350, as adopted pursuant to Section听906 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March听31, 2011.
听	听	听
Exhibit听32.2	听	Certification by Rao Uppaluri, Chief Financial Officer pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 for the quarterly period ended March 31, 2011.