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Form: 4

Statement of changes in beneficial ownership of securities

February 29, 2008


JOINT FILER INFORMATION

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NAME:
Frost Gamma Investments Trust
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ADDRESS:
4400 Biscayne Blvd
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Miami, FL 33137
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Designated Filer:
Phillip Frost, M.D.
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Issuer and Ticker Symbol:
Opko Health, Inc. (OPK)
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Date of Event Requiring
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Statement:
February 29, 2008
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FROST GAMMA INVESTMENTS TRUST

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by:
/s/ Phillip Frost MD, as trustee
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Phillip Frost, M.D., Trustee

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